Can medicine help phantom limb pain?

There are no drugs specifically for phantom limb pain. But medicines for other conditions, from depression to epilepsy, may help:

Other painkillers. A few other types may help with phantom limb pain, including:

  • Tricyclic antidepressants
  • Anticonvulsants
  • Opioids
  • NMDA receptor antagonists, such asketamine and dextromethorphan
  • Over-the-counter medicine, such as aspirin and acetaminophen
  • A shot of a pain-blocking drug where you got the amputation