On March 20, 2020, President Trump touted hydroxychloroquine, a common anti-malaria drug, as a potential treatment for the illness, even while the top health official beside him urged caution about it. Whether HCQ is as efficacious as CQ in treating SARS-CoV-2 infection still lacks experimental evidence. We need to point out, although HCQ is less toxic than CQ, prolonged and overdose usage can still cause poisoning. FDA commissioner warns public against taking ‘any form of chloroquine’ unless prescribed.